Scholarship 22/15680-6 - Diagnóstico, Epigenômica - BV FAPESP
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Identification of long non-coding RNAs and their targets in the metacarpophalangeal joint of horses affected by osteoarthritis.

Grant number: 22/15680-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: April 01, 2023
End date until: March 31, 2024
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Principal Investigator:Flavia Lombardi Lopes
Grantee:Lívia Wolff Bueno Rodrigues
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Osteoarthritis (OA) is a very common pathological condition in several species, characterized by impairment of the joint due to its degenerative nature. In veterinary medicine, this condition is often associated with sport horses, mainly due to the intense training and work load. These stimuli can lead to synovitis and, consequently, to a progressive deterioration of the articular cartilage, followed by bone and soft tissue alterations, osteoarthritis. Athlete horses diagnosed with OA are animals that lose athletic performance and may be retired from their functions for this reason, generating economic losses for the breeder and animal welfare. In addition to external factors that predispose to OA, intrinsic genetic and epigenetic factors regulate the inflammatory process. Understanding these physiological and pathological factors, which participate in the establishment and progression of OA, can enable the development of an early diagnosis, facilitating treatment and providing a better prognosis for the animal. Among the epigenetic processes, long non-coding RNAs (lncRNAs) stand out, capable of regulating gene expression in a pre- and post-transcriptional manner. Specific lncRNAs are involved with extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis and angiogenesis in humans and rats, processes associated with the development of OA. The present work aims to identify differentially expressed lncRNAs in the synovial fluid of equine joints affected by OA and to identify possible cis and trans targets of differentially expressed lncRNAs, as well as their biological functions and relevance in OA.

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