Scholarship 22/14868-1 - Biomarcadores, Crustacea - BV FAPESP
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Whole transcriptome analysis of the burrowing amphipod Tiburonella viscana exposed to contaminated sediments.

Grant number: 22/14868-1
Support Opportunities:Scholarships in Brazil - Master
Start date until: February 01, 2023
End date until: May 31, 2025
Field of knowledge:Physical Sciences and Mathematics - Oceanography - Biological Oceanography
Principal Investigator:Lucas Buruaem Moreira
Grantee:Olívio de Araujo Netto
Host Institution: Instituto do Mar (IMar). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Associated research grant:20/00068-8 - Whole transcriptome analysis of benthic organisms as models to estimate toxic effects of contaminated sediments in marine environments, AP.BTA.JP
Associated scholarship(s):24/00963-8 - Bioinformatics in marine ecotoxicology: transcriptome of the amphipod Tiburonella viscana, BE.EP.MS

Abstract

Sediment toxicity bioassays are used for the evaluation of the ecological risks produced by contaminants, which are related to biodiversity loss in benthic environments. In Brazil, there are few benthic models for these bioassays, and for those already established, the knowledge is incipient regarding the mechanisms of toxicity that are activated, generating effects at different levels of biological organization. Such models include the excavating amphipod Tiburonella viscana, which has a high sensitivity to contaminants. In this research project, we aim to investigate the molecular mechanisms of toxicity of the species by using transcriptomic analysis of animals collected in the field and exposed to contaminated sediments in the laboratory. We hypothesize that this technique will provide evidence of initiating events of toxic responses in T. viscana, related to a higher susceptibility of the species, and also the potential activation of signaling pathways involved in the response to contaminants. The experimental design is set to obtain the functional annotation of differential gene expression by using the RNA sequencing technique (RNAseq). The goal is to investigate the activation of toxicity pathways in T. viscana that can be used as biomarkers. Therefore, the results of this project will provide relevant information on the biological aspects of the species, and also advances in marine ecotoxicology, since the use of a mechanistic approach in sediment evaluations is moving forward with the knowledge on this topic.

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