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Investigation on the role of the flavohemoglobin Yhb1 during genotoxic stress response on Saccharomyces cerevisiae yeast

Grant number: 22/15333-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2023
Effective date (End): December 31, 2023
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:José Renato Rosa Cussiol
Grantee:Júlia dos Santos França
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:18/05417-0 - DNA damage signaling pathways: mechanisms of regulation and cross-talk with cellular metabolism, AP.JP

Abstract

Chromatin damages can be caused by a series of endogenous and exogenous factors that lead to alterations and breaks on DNA, replication forks collapse, histones and other nucleus' proteins damage, besides other organelles damages such asmitochondria's with consequent increase of oxygen and nitrogen reactive species (ORSs and NRSs). Failure in appropriate cellular response during genotoxic stress can lead to genomic instability with consequent loss of cellular viability. Previous studies showed that during genotoxic stress on Saccharomyces cerevisiae, multiples proteins present an increasing level and alter their cellular localisation. It was observed that Yhb1 (ortholog of human neuroglobin NGB), a flavohemoglobin with nitric oxide reductase activity, has its levels increased during genotoxic stress induced by the genotoxic agent MMS. Besides, previous data using quantitative proteomic approach shows that after MMS treatment, there was an enrichment of Yhb1 in mitochondrial fraction. Therefore, we intend to investigate the role of Yhb1 during genotoxic stress and a possible cross-talk between mitochondrial function.

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