Evaluation of the TG/HDL ratio as a marker to identify the cardiometabolic profile in women with gestational diabetes

Abstract

GDM is the most common metabolic disorder during pregnancy. The condition increases maternal risks for the development of DM2, hypertension, preeclampsia, cesarean delivery, among others. The current diagnosis is based on OGTT with 75g of glucose, disregarding the spectrum of insulin resistance and the variety of cardiometabolic profiles, demonstrably related to different maternal-fetal outcomes and prognosis. Thus, the study of TG/HDLc, little studied in this regard, may bring new relevant information for its application in the characterization and stratification of the different IR and cardiomatebolic profiles in patients with GDM. Methods: The design of the present study is cross-sectional, with data collected during the pregnancy of 1064 women from the Diabetes and Pregnancy outpatient service at UNIFESP, referring to high-risk prenatal care from January 2008 to November 2021. The data will be anonymized: the patients and their data will be listed without identifying the name at the time of data analysis. The exposure variable will be the ratio between triglycerides and HDL-cholesterol in the second or third trimester of pregnancy: TG/HDL. The variable will be used continuously or stratified into tertiles, and the independent variables (outcome and covariates) will be compared between groups, with the significant p value fixed at 5%.