Advanced search
Start date

Assessment of Autonomic Cardiovascular Neuropathy and Peripheral Artery Disease in Patients with Type 2 Diabetes Mellitus in Support of the Risk Stratification Strategy and Referral to Complementary Exams in Clinical Practice.

Grant number: 22/13673-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2023
Effective date (End): December 31, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Andrei Carvalho Sposito
Grantee:Maria Clara Pimenta de Figueiredo
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Type 2 diabetes mellitus is a disorder of glucose metabolism, a clinical, progressive syndrome whose main mechanism is insulin resistance. For the next two decades, there is a prospect that almost 700 million individuals will be affected by DM2. Patients with DM2 have up to 3x higher cardiovascular mortality compared to healthy individuals. And, due to its pathophysiological mechanisms, DM2 is a high risk factor for the occurrence of peripheral arterial disease (PAD) and autonomic cardiovascular neuropathy (ACN). PAD is an independent risk factor for major cardiovascular events, including ischemic stroke, myocardial infarctions, and cardiovascular death; and ACN, characterized by damage to the fibers of the autonomic nerves that innervate the heart and blood vessels, leading to abnormalities in heart rate and vascular dynamics, is associated with myocardial ischemia, coronary artery disease, QT segment prolongation, and to strokes. To face this reality, it is possible to use non-invasive, clinically reproducible strategies for screening and selecting patients with a greater indication of being submitted to specialized evaluation, in order to refer them for possible complementary tests and adequate the most indicated therapeutic strategies. Among these strategies, the Ankle Brachial Index and the Ewing Test can be highlighted, which assess PAD and ACN, respectively. Therefore, evaluating the relationship between these two conditions can help in patient risk stratification and for more effective prevention and treatment strategies.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: