Advanced search
Start date

Identification of new pathways and compounds that enhance Caspofungin and Voriconazole activity against Aspergillus fumigatus

Grant number: 22/08556-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2022
Effective date (End): September 30, 2024
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Gustavo Henrique Goldman
Grantee:Laura Cristina Garcia Carnero
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:21/04977-5 - The identification of new pathways and compounds that can enhance caspofungin activity against Aspergillus fumigatus, AP.TEM


This project has the following objectives: (i) to screen the LifeArc library ( for compounds that can synergize caspofungin or voriconazole in A. fumigatus wild-type and caspofungin-, and voriconazole-resistant strains (ii) to characterize the mechanisms of action of the most promising compounds found in the LifeArc library, by several tools such as screening of null mutant libraries (transcription factor, kinase, and phosphatase libraries) and (iii) to characterize the transcriptional profiling of A. fumigatus wild-type and a putative more drug sensitive null mutant when exposed to one of the selected compounds through RNAseq. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: