Advanced search
Start date

The role of Tamm-Horsfall protein in acute kidney injury and transition to chronic kidney disease

Grant number: 22/08271-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): March 20, 2023
Effective date (End): March 19, 2024
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Maria Oliveira de Souza
Grantee:Larissa de Araújo
Supervisor: Tarek Maurice Ashkar
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Indiana University School of Medicine, United States  
Associated to the scholarship:21/09277-1 - Crystalline nephropathy in mice: the role of Tamm-Horsfall protein in Acute Kidney Injury and its progression to Chronic Kidney Disease, BP.DD


Acute kidney injury (AKI) is a major determinant of mortality and morbidity in hospitalized patients. Understanding the pathophysiology of AKI is essential for the development of therapy. Furthermore, AKI itself can lead to de novo chronic kidney disease (CKD) and progression towards end stage kidney disease. This application proposes to study the role of Tamm-Horsfall protein (THP) in regulating the susceptibility and severity of AKI and the transition to CKD. THP is expressed exclusively in the kidney by cells of the thick ascending limbs (TAL) of Henle. THP deficiency enhances the severity of AKI, and this protein has a protective role by inhibiting inflammatory signaling in proximal tubules and regulating macrophage function. The immediate goal of the current proposal is to advance our developing knowledge of the role of THP in immunomodulating kidney injury and repair and use this knowledge to transition into therapeutic applications. The central hypothesis for this application is that THP is essential to promoting recovery from AKI and progression to CKD by promoting tubular repair and enhancing the activity of renal macrophages needed for healing. This hypothesis will be investigated using 2 specific aims. Aim 1 will define the role of THP on tubular injury/repair and homeostasis of renal macrophages during AKI. Aim 2 will define the role of THP long term fibrosis and progression to CKD. This research is innovative, because it will uncover novel regulatory functions for THP in injury and repair and will pave the way to develop novel therapeutic strategies using recombinant THP. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: