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Perinatal COVID-19 infection: relation with maternal infection and clinical features of neonates

Grant number: 22/09207-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2022
Effective date (End): September 30, 2023
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Fabíola Isabel Suano de Souza
Grantee:Giovana Leite Gonçalves
Host Institution: Centro Universitário. Faculdade de Medicina do ABC (FMABC). Organização Social de Saúde. Fundação do ABC. Santo André , SP, Brazil

Abstract

Introduction and justification: Pregnant women and children seems to have the mild illness of COVID-19 or have similar symptoms as non-pregnant women. However there is limited data available about the possibility of vertical transmission and the evolution of neonates, whose mothers tested positive for COVID-19 in some point of the pregnancy, that test positive for SARS-CoV-2 in the firsts hours of life. Thereby, we decided to do this study. Objective: To describe the clinical features and evolution of neonates who tested positive for COVID-19 in the first 48 hours of life and relate its clinical and laboratory characteristics with the presence and time interval of maternal infection by COVID-19 during pregnancy, severity of maternal disease, type of delivery, birth weight, gestational age, skin-to-skin contact and breastfeeding. Methods: This is a case-control study with 93 pairs of mothers who contracted COVID-19 during pregnancy and neonates (31 cases e 62 controls). Their medical records will be analyzed to fill out a questionnaire. Expected results: We expect to find possible associations between maternal COVID-19 infection and neonate's COVID-19 infection, besides possible relations between the infection and changes in the development and evolution of neonates. Expected difficulties: We expect to find difficulties in guaranteeing that the neonatal infection has occurred by vertical transmission, in addition to characterizing the changes that COVID-19 may have caused in neonates.

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