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Effect of The Absence of The Splicing Factor Cwc24 on Prp11 Interactome in Saccharomyces cerevisiae

Grant number: 22/06549-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2022
Effective date (End): September 30, 2023
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Carla Columbano de Oliveira
Grantee:Emerson Fernando Balan
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:20/00901-1 - Posttranscriptional control of gene expression: pre-rRNA processing, mRNA degradation, splicing and snoRNP assembly in Saccharomyces cerevisiae, AP.TEM


Most eukaryotic genes contain non-coding sequences, called introns, that are removed during splicing. This maturation process is carried out by the spliceosome in conjunction with hundreds of evolutionarily conserved factors, including the Cwc24 protein, which binds to the 5' end of the intron, protecting it. The binding of Cwc24 to the pre-mRNA and the spliceosome is temporary, but its absence appears to affect the activity of the small nuclear ribonucleoprotein U2 and is also related to aberrant forms of splicing. The mechanism that promotes binding and, subsequently, the release of Cwc24 from the complex, has not yet been discovered. This project aims to analyze the interactions of the splicing factor Prp11, present in one of the subcomplexes of U2, in the absence of Cwc24, in order to better characterize its function.

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