Advanced search
Start date

Rankl on the expression of mitochondrial biogenesis markers in miotubes

Grant number: 22/06359-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2022
Effective date (End): February 28, 2023
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Mariana Kiomy Osako
Grantee:Maria Eduarda Ramos Cezine
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The bone-muscle operational unit refers to the mechanical interaction between bone and muscle and the communication via soluble factors that reciprocally regulate their metabolism. RANKL (receptor activator of NFkB ligand) and OPG (osteoprotegerin) are examples of bone-specific proteins that, together with RANK (receptor activator of NFkB), are essential for osteoclast activation and bone resorption in processes of bone remodeling. Especially those involving mitochondrial biogenesis and an increase in oxidative capacity. Our group has recently shown the function of the RANK-RANKL signaling to increase the mitochondrial volume and differentiation of beige adipocytes, a process described as browning. Preliminary data from our lab indicates the role of RANK-RANKL in metabolism control and energy efficiency and its contribution to functions related to the mitochondrial dynamics in the skeletal muscle cells after the RANKL treatment. Mitochondrial dynamics events, such as fusion, fission, and biogenesis, are regulated by PGC1-z expression, which is a transcription factor essential for increasing mitochondrial content and adaptation to energetic demand in the skeletal muscle tissue. Therefore, this project aims to analyze the effect of RANKL on the gene expression of mitochondrial biogenesis markers in myotubes derived from the cell line C2C12 and its impact on metabolism control and energy efficiency.(AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: