Advanced search
Start date

Micro-structural brain white matter alterations in retired soccer players in Brazil

Grant number: 21/14991-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2022
Effective date (End): August 31, 2023
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:Maria Concepción García Otaduy
Grantee:Bernardo Fernandes Pelinca da Costa
Host Institution: Instituto de Radiologia (INRAD). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Despite the well-established benefits in the scientific literature of practicing sports, some practices present risks to head trauma. Traditional examples - with scientific evidence backing them up - are boxing and American football. However, soccer players are also subjected to several episodes of head trauma during their careers. These traumas can happen with collisions with the metal bars in the goal, the ball, and other players during physical contact. The hypothesis is that these events lead to cerebral lesions related to chronic traumatic encephalopathy (CTE). Radiologically, this can be associated with alterations in the brain's white matter, leading to possible functional deficits; as observed in previously described clinical cases involving retired soccer players. To evaluate these white matter alterations, the inhomogeneous magnetization transfer (ihMT) method for magnetic resonance was chosen; due to its higher sensitivity and specificity to myelin - white matter's main component - than other available methods. In this retrospective case-control study, 39 Brazilian males were selected, 20 of them retired soccer players and the best part of the control group. Between 2017 and 2019, these participants were subjected to a PET MRI exam with a 7T MRI and direction anamnesis for collecting relevant medical data for each participant. The images obtained in the MRI are going to be processed using both neuroimaging software FSL and FreeSurfer, followed by a statistical analysis of obtained data. The expected result is a statistically significant decrease in the myelin content observed in the case group compared to the control group.(AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: