The great performance of polygenic risk scores (PRS) has already been demonstrated for some physiological variables, such as blood pressure. In the case of mental disorders, several studies have also replicated, in several target samples, the effects of PRSs for schizophrenia, major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD), among others. However, most discovery samples are essentially of European ancestry, collected in developed countries, resulting in a Eurocentric and population-homogeneity bias in genomic scanning association studies (GWAS). Because of this, it is extremely important to assess how the environmental and/or epigenomic background of heterogeneous populations with high rates of social inequalities, such as the Brazilian population, mediates or moderates the polygenic effect on the susceptibility and severity of mental disorders. Therefore, the general objective of the project, which is linked to the umbrella project "The Physiological Genomics of Mental Health from the Optical of the Brazilian Exposoma", is to assess how environmental and epigenomic variables modulate the effect of the most studied PRSs in psychiatric biology.
News published in Agência FAPESP Newsletter about the scholarship: