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Identification of immune evasion mechanisms in myeloid leukemias by mapping natural killer cells by single-cell transcriptomics

Grant number: 22/09394-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2022
Effective date (End): November 30, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Lorena Lôbo de Figueiredo Pontes
Grantee:Camila Araujo Bernardino Garcia
Host Institution: Hemocentro de Ribeirão Preto. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
Associated research grant:21/06841-3 - Molecular and phenotypical mechanisms driving immune evasion in myeloid malignancies, AP.JP2

Abstract

Advances in immunotherapy have already been achieved with checkpoint inhibitors to enhance T cell responses such as inhibition of PD-1/PDL-1 in solid tumors and lymphoproliferative diseases, with promising results, and more scarce data from clinical trials in myeloid leukemias, as well as with Genetic Engineering of T lymphocytes (CAR-T cell therapy). However, for myeloid diseases, this therapy still faces great limitations due to the difficulty of targeting specific leukemic antigens that are not present in normal cells. Leukemic initiating cells are resistant to the immune system, either by deficiency of ligands at the level of the tumor cell, or by deficiency of receptors or molecules essential for the performance of effector cells. In this context, a deep characterization of innate lymphoid cells, in particular Natural Killer (NK) cells, deserves investigation, and can be the scientific base for developing strategies to reestablish the antitumoral immunity, especially for myeloid malignancies, yet unfortunately rarely curable. (AU)

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