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Effect of the association of breathing and aerobics exercises with constant load on clinical control, psychosocial aspects and sleep quality of patients with moderate to severe asthma: randomized controlled clinical trial

Grant number: 22/09941-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2022
Effective date (End): December 31, 2023
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Celso Ricardo Fernandes de Carvalho
Grantee:Vitoria Zacarias Cervera
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/17788-3 - Pulmonary rehabilitation: effect of new patient-centered methodologies and technologies in patients with chronic pulmonary diseases, AP.TEM


Non-pharmacological treatments have been used to improve clinical control in asthmatic patients. Aerobic and breathing exercises have been the most studied treatments, but the inclusion of one of these treatments varies across the world. A recent study suggests that both treatments have an effect on improving clinical control; however, a study that associates the two treatments is unknown until nowadays. Objective: To evaluate the effect of the association of aerobic and breathing exercises on the clinical control of asthma in patients with moderate to severe persistent asthma. Methods: a randomized controlled trial that will include 54 patients with asthma who have been on treatment for at least 6 months and have not had an exacerbation in the last 30 days. Patients will be randomized into 2 groups: only aerobic exercise+placebo (stretching) (GAA) or aerobic+respiratory exercise (GAR). All of the participants will get into an asthma education program before the start of the intervention. The training program will last for three months and will be carried out for 20 sessions, twice a week, lasting 70 minutes each session. Breathing exercises were performed using the Buteyko technique. All patients will be evaluated before and after the intervention for clinical control (ACQ), health factors related to the quality of life (AQLQ), levels of anxiety and depression (HADS), symptoms of hyperventilation (Nijmegen), and physical capacity (Incremental Shuttle Walking Test). To identify possible differences between groups and/or over time, the t test will be used for comparisons between delta, and for categorical variables, the chi-square test. The significance level will be set to 5% (p less than 0.05) for all tests.(AU)

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