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Effect of swimming exercise on apical periodontitis: pulp/periapical bacteriological analysis and repair of collagen fibers

Grant number: 22/04884-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2022
Effective date (End): August 31, 2023
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Rogerio de Castilho Jacinto
Grantee:Michely de Lima Rodrigues
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Apical Periodontitis (AP) is the result of bacterial infection of the root canal. The inflammatory response of the host, in an attempt to suppress the microorganisms, intensifies the process, generating a loss of bone support, tooth resorption, and pain. The practice of physical activity sensitizes the immune system, leaving the body less vulnerable to inflammation and infections. In addition, physical exercise was able to reduce the intensity of inflammation caused by PA. Thus, the objective of this study is to investigate the effects of swimming exercise on apical periodontitis, developed in rats, analyzing the presence of bacteria inside the root canal and periapical region and the repair capacity of collagen fibers in the dental periapical. Twenty male Wistar rats will be divided into 2 groups of 10 rats each: C+PA group and T+PA group. The protocol will occur in two stages: adaptation to the aquatic environment and training. Apical periodontitis will be induced on the 28th day and the rats will be sacrificed on the 58th day by anesthetic overdose. The upper molars will be collected and processed for histological analysis with Picrosirius Red (PSR) and Brown-Brenn (B&B). The collected data will be tabulated and statistically analyzed using the SigmaPlot 12.0 program (Systat Software Inc., San Jose, USA) at a significance level of 5%.(AU)

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