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miRNAs cargo in extracellular vesicles and their ability to induce immunosenescence in patients living with HIV

Grant number: 22/04593-5
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2022
Effective date (End): September 30, 2023
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Fabiani Gai Frantz
Grantee:Ricardo Cardoso Castro
Supervisor: Kenneth W. Witwer
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Johns Hopkins University (JHU), United States  
Associated to the scholarship:19/11422-0 - Study of immunological and epigenetic markers of extracellular vesicles and their ability to induce early immunosenescence related to HIV infection, BP.DR


The Human Immunodeficiency Virus (HIV), which causes the acquired immunodeficiency syndrome (AIDS) is considered a major public health problem worldwide. More recent data made available by the World Health Organization (WHO) has shown that in 2020, about 37.7 million people are living with HIV worldwide. With the emergence of antiretroviral therapy (ART), the infection was no longer considered a lethal disease and acquired a profile of chronicity. Given this, over the years it has been observed that people living with HIV (PLWH) have presented a systemic and chronic inflammatory profile that can favor the process of immune dysfunction and consequently provide immunological senescence. Interestingly, studies have already shown that miRNAs present in extracellular vesicles (EVs) participate in and regulate processes that govern cellular senescence and consequently influence aging. Considering the biological and functional aspects between EVs and miRNAs, the objective of this work is to investigate the presence of immunosenescence-associated miRNAs in samples of EVs isolated from plasma and in peripheral blood mononuclear cells (PBMCs) of PLWH and to assess the ability of these Specific miRNAs induce immunosenescence of PBMCs from healthy subjects. In this way, this study will contribute to the understanding of mechanisms related to immunosenescence during HIV infection and will help in the search for new molecular targets and biomarkers aimed at reducing systemic inflammation in PLWH. (AU)

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