Scholarship 22/03364-2 - Carrapatos - BV FAPESP
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The liver and spleen of hosts of ticks Rhipicephalus sanguineus l.s. exposed in the laboratory to synthetic (afoxolaner) and natural (esters derived from castor oil) acaricide bases. A comparative clinical-morphological study.

Grant number: 22/03364-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: June 01, 2022
End date until: December 31, 2022
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Maria Izabel Souza Camargo
Grantee:Odaiza da Silva
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil

Abstract

The species Rhipicephalus sanguineus l.s., commonly known as the brown dog tick, has canids as its main host, and has been considered important for causing several infectious diseases in them. Chemical products with synthetic bases have been systematically used to control this ectoparasite however, the use of these products, despite being efficient, has been causing damage not only to the health of the host, but also to the environment. In this sense, many studies have had the purpose to search substances that can control these ectoparasites without causing damage to non-target animals, including the hosts. Thus, the present proposal to develop a comparative study that has the hosts as a biological model and not the ectoparasites, evaluating in a comparative way the toxic potential of a chemical synthetic,afoxolane (Nexgard®), and a natural bioactive derived from ricinoleic acid from castor oil (esters). This natural bioactive have already proven their efficiency as acaricide in laboratory experiments and now, at this stage, we intend to confirm whether they can be toxic when the hosts exposed to them have the liver and spleen analyzed morphophysiologically and clinically. In addition to morphological, histology and histochemistry studies, analysis tests of the dosages ALT, AST and FA enzymes will also be performed, these informations will be important for the recommendation of the field use of esters derived from castor oil as a control agent for R. sanguineus l.s ticks.

News published in Agência FAPESP Newsletter about the scholarship:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SODELLI, LUIS FERNANDO; DA SILVA, ODAIZA; ARAUJO, BRUNA JESSYCA NASCIMENTO; CAMARGO-MATHIAS, MARIA IZABEL. Liver and spleen of hosts of Rhipicephalus linnaei exposed to synthetic (afoxolaner) and natural acaricides (esters from castor oil). A comparative clinical-morphological study. REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA, v. 32, n. 3, p. 13-pg., . (22/03364-2)

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