Advanced search
Start date
Betweenand

Construction of tagging and knockdown systems of the serpentine receptor 10 (SR10) in Plasmodium falciparum

Grant number: 22/06132-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2022
Effective date (End): December 31, 2022
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Célia Regina da Silva Garcia
Grantee:Giovana Cavassani Travaini
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/08684-7 - Decoding Plasmodium signaling at molecular level as a new tool to the development of new antimalarials, AP.TEM

Abstract

Malaria is a disease transmitted through the bite of Anopheles mosquitoes, which can be caused by Plasmodium falciparum, a parasite responsible for the most severe cases of malaria in the world. Its life cycle involves several stages, including a developmental intraerythrocytic stage, where the parasite invades its host's erythrocyte cells to undergo maturation and proliferate, continuing the infection. During this stage of asexual maturation and proliferation, many mechanisms come into play to regulate factors important to development and parasite survival. Some of these mechanisms are controlled by stimuli received through serpentine receptors, proteins that contain seven transmembrane domains and are expressed at different stages of the cycle of the parasites. Among these receptors is SR10 which still has not had its function properly clarified, although there are indications and theories about it. Thus, the objective of this project is the development of genetically modified P. falciparum to carry out the tagging and gene knockdown of the theSR10 receptor, seeking to perform subcellular localization and receptor functional analysis at different stages of the intraerythrocytic cycle of P. falciparum.(AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.