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Development and study of a plasma system generated by dielectric barrier discharge (DBD) for continuous activation of liquids applied in dental treatments

Grant number: 21/14181-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): May 01, 2022
Effective date (End): April 30, 2025
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Cristiane Yumi Koga Ito
Grantee:Felipe de Souza Miranda
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
Associated research grant:19/05856-7 - Use of low temperature atmospheric pressure plasma in dentistry: from laboratory bench to clinics, AP.TEM


The antimicrobial, anti-inflammatory and tissue repair-inducing actions promoted by reactive species generated by the plasma and its low toxicity are promising characteristics that can be applied in the treatment of diseases in the dental areas. In this context, this proposal aims to investigate the applications of cold atmospheric pressure plasma (LTAPP) in Dentistry. The general objective is to develop a system for activating nebulized liquids using plasma generated from a dielectric barrier discharge (DBD) for application in a single step, with no need to activate the liquid prior to the treatment process. As specific objectives, it is intended to establish the physical operating parameters of the DBD system. Chemical characterizations of the plasma will be performed to identify the species generated in order to assess the effectiveness of the process in activating nebulized liquids. The activated liquid will be collected to determine the effectiveness of the activated liquid in vitro and in vivo antimicrobial tests on biofilms related to oral diseases. Subsequently, these parameters will be evaluated for cytotoxicity and genotoxicity, adopting the most appropriate cell line for each case. The effective (maximum antimicrobial effect) and safe (less toxicity) protocols will be applied in in vivo or ex vivo models for validation. In short, after the validation tests of the system and effectiveness of the method, it is intended to develop a robust and compact prototype that is easy to operate to be used in dental clinics.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KOGA-ITO, CRISTIANE YUMI; KOSTOV, K. G.; MIRANDA, F. S.; MILHAN, N. V. M.; NETO, N. F. AZEVEDO; NASCIMENTO, F.; PESSOA, R. S.. Cold Atmospheric Plasma as a Therapeutic Tool in Medicine and Dentistry. PLASMA CHEMISTRY AND PLASMA PROCESSING, v. N/A, p. 37-pg., . (16/07196-6, 21/14181-3, 23/02268-2, 19/05856-7, 20/09481-5)

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