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New approach to delivery beta: tricalcium phosphate nanoparticles for tooth remineralization

Grant number: 22/00633-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 01, 2022
Effective date (End): June 30, 2023
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Taís Scaramucci Forlin
Grantee:Leonardo Custódio de Lima
Supervisor abroad: Sabrina Feitosa Sochacki
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Indiana University, United States  
Associated to the scholarship:20/07986-2 - Synthesis of an experimental vehicle for the application of nanometric Beta-TCP particles functionalized with fluoride and stannous for the control of dentin surface loss and dentin hypersensitivity, BP.DR

Abstract

The aim of this study is to synthesize an experimental adhesive containing ²-TCP nanoparticles and characterize it in terms of biological, chemical and physical properties. The variation factor will be experimental adhesive, in 3 levels: 1. Positive Control: Commercial Adhesive (SBMP); 2. Experimental adhesive with ²-TCP nanoparticles and 3. Experimental adhesive without ²-TCP nanoparticles. To characterize the experimental material, 1. degree of conversion (% DC); 2. Knoop hardness (KHN); 3. Flexural strength (FS) and 4. Cytotoxicity (% cell viability) will be evaulated. Experimental dentin adhesive resins will be prepared by mixing Bis-GMA, TEGDMA, HEMA (50/25/25 wt.%), and photo-initiators and inhibitors. ²-TCP nanoparticles will be incorporated into the resin mixture at distinct concentrations, according to a pilot study. For the cytotoxicity and hardness tests, disc-shaped specimens (10 mm in diameter × 1 mm thick) will be prepared for each group (n = 3). For the flexural strength test, bar-shaped specimens (25 mm long × 2 mm wide × 2 mm thick) will be prepared for each group (n = 5) according to the ISO 4049. Data will be analyzed statistically using appropriate methods (± = 0.05). (AU)

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