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Evaluation of the physical-mechanical and microbiological properties of a new resin-modified glass ionomer cement containing nanoparticles of sodium trimetaphosphate and phosphoryl chitosan: in vitro study

Grant number: 21/05532-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2022
Effective date (End): February 28, 2023
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Marcelle Danelon
Grantee:Gabriela Leal Peres Fernandes
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The aim of this study is to evaluate the effect of incorporating sodium trimetaphosphate nanoparticles (TMPnano) and phosphorylated chitosan (Qui-Ph) in resin-modified glass ionomer cement (RIMIC) used for cementation of orthodontic brackets, on the physical-mechanical, anticarious and antimicrobial properties. Specimens of each material will be made: 1) CIVMR without TMPnano/Qui-Ph (Positive Control-Fuji Ortho LC); 2) CIVMR with 14% TMPnano (CIVMR-TMPnano); 3) CIVMR with 0.25% Qui-Ph (CIVMR-0.25%Chi-Ph; 4) CIVMR with 0.5% of Qui-Ph (CIVMR-0.25%Chi-Ph; 5) CIVMR with 14% of TMPnano and 0.25% of Qui-Ph (CIVMR-TMPnano-0.25%Qui-Ph) and 6) CIVMR with 14% of TMPnano and 0.5% of Qui-Ph (CIVMR-TMPnano-0.5%Qui-Ph). The physical-mechanical properties of the CIVMRs will be determined: diametrical tensile strength (RTD), compressive strength (CR), hardness (D), surface roughness (SR) and morphological analysis of the CIVMRs containing or not containing TMPnano-Qui-Ph by scanning electron microscopy (SEM). The chemical composition of the samples will be determined by energy dispersive X-ray spectroscopy (EDX), and antimicrobial and antibiofilm activity will be evaluated by agar diffusion test and biofilm metabolism. For statistical analysis, RTD, RC, D, RS values and biofilm data will be considered as variables, and the type of CIVMR will be considered as a variation factor. If parametric tests are possible, the data will be submitted to ANOVA, followed by the Student-Newman-Keuls test, using the statistical program SigmaPlot®, with 5% significance level.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERNANDES, Gabriela Leal Peres. Evaluation of the physical-mechanical and microbiological properties of a new resin-modified glass-ionomer cement containing nanoparticles of sodium trimetaphosphate and phosphorylated chitosan: in vitro study.. 2023. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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