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Impact of recreational physical exercise on inflammatory parameters and executive function of students and staff kept physically inactive during the COVID-19 pandemic period

Grant number: 21/06338-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2022
Effective date (End): December 31, 2022
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Fábio Santos de Lira
Grantee:Ivete Vera Medeiros dos Santos
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


During the period of the COVID-19 pandemic, studies have shown a high rate of sedentary behavior, physical inactivity, mood disorders, and reduced sleep quality, in parallel with a reduction in physical exercise. The importance of physical exercise for the maintenance of physical and mental health is well established in the literature, exerting positive effects in the treatment of cognitive dysfunctions, depressive and anxiety disorders, reduction of adipose tissue deposits, and metabolic dysregulation, including by presenting anti-inflammatory effects. Therefore, the objective of this project is to evaluate the impact of eight weeks of physical training on metabolic and inflammatory (immunometabolic variables) and mental (mood and executive function) parameters of students and employees of the Faculty of Science and Technology (FCT) of UNESP after the release of social distance resulting from the COVID-19 pandemic. For this, participants will be randomized into groups (control and intervention) and will have immunometabolic parameters (body composition, lipid profile, glucose, insulin, PAI-1, BDNF, adiponectin, and leptin) and mental health parameters (anxiety, depression, and executive function) assessed at the beginning and at the end of the recreational physical training program. It is expected that post-social distancing physical exercise contributes to the improvement of the immunometabolic profile and mental health parameters and, therefore, influences the improvement of mood and performance of the executive function.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, BRUNA SPOLADOR DE ALENCAR; PEREIRA, TELMO; MINUZZI, LUCIELE GUERRA; PADILHA, CAMILA SOUZA; FIGUEIREDO, CAIQUE; OLEAN-OLIVEIRA, TIAGO; DOS SANTOS, IVETE VERA MEDEIROS; VON AH MORANO, ANA ELISA; MARCHIOTO, OSMAR; RIBEIRO, JOSE PROCOPIO JABUR; et al. Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level- an observational sub-analysis fit-COVID study. FRONTIERS IN IMMUNOLOGY, v. 14, p. 16-pg., . (20/07765-6, 21/11932-8, 21/06338-0, 19/26378-6, 19/25626-6, 18/23402-0)

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