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Evaluation of antimicrobial activity of bioceramics against multidrug-resistant strains

Grant number: 21/13122-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2022
Effective date (End): January 31, 2023
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Paola Castro Moraes
Grantee:Mariana Bugov
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Several bioceramics are developed and applied in animal models to obtain faster bone repair, such as calcium phosphate cement and biopolymers. However, postoperative infections of the implanted area inevitably lead to the resorption of much of the implant or its total loss by microbial colonization and biofilm formation on the surface of bioceramics. Widespread use of antimicrobials for several decades has led to an increased prevalence of multidrug-resistant bacteria, challenging our ability to treat bacterial infections. Some bioceramic formulations have antibacterial properties because they damage bacterial structures and walls. This work aims to evaluate the antimicrobial activity of four different bioceramic formulations (Porous Synthetic Hydroxyapatite, Lumina-Bone®, bioglass 45S5, and boro-silicate bioglass) against multidrug-resistant microorganisms commonly involved in surgical site infection by conducting microdilution susceptibility test in broth.(AU)

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