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HOXA 11 gene expression in women with pelvic organ prolapse: a pilot study

Grant number: 21/09518-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2021
Effective date (End): November 30, 2022
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Luiz Gustavo Oliveira Brito
Grantee:Luana Amorim Hassun
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Background: genital prolapse is a growing disease and there are several factors involved in its pathogenesis. Genetically, it is a disease that is caused by an alteration of collagen and elastin; however, not all factors are known to be responsible for it. The homeobox gene (HOXA) is possibly related to this disease. Objectives: to assess the protein and immunohistochemical expression of the HOXA11 gene of women with genital prolapse and control patients (no genital prolapse) Methods: A prospective study with 50 women with genital prolapse will be performed at CAISM and 50 women without genital prolapse (control group) and sampling will be sent to perform RT-PCR, western blot and immunohistochemistry for the identification of HOXA11 gene. Expected results: We believe that by the identification of the protein expression., HOXA11 gene may serve as a predictor of genital prolapse for these patients. Time schedule: twelve months for data collection and sampling storage; six months to analyze data and prepare a manuscript for submission.(AU)

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