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CALORIMETRIC ANALYSIS OF SACCHAROMYCES CEREVISIAE STRAIN PE-2 UNDER SPECIFIC METABOLIC STAGES AND INDUSTRIAL RELEVANT CONDITIONS

Grant number: 21/13701-3
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 23, 2022
Effective date (End): March 22, 2023
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal researcher:Thiago Olitta Basso
Grantee:Kevy Pontes Eliodório
Supervisor abroad: Thomas Maskow
Home Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Helmholtz Association, Germany  
Associated to the scholarship:19/08393-8 - Experimental study and mathematical modeling of the alcoholic fermentation process considering thermal effects, BP.DR

Abstract

Extreme conditions are expected during sugarcane ethanol production that make the process difficultto be modelled. Saccharomyces cerevisiae cells deal with many stressful factors during fermentation,such as high-cell density, inhibitory compounds, lack of essential nutrients, non-aseptic conditions,and high temperature. Despite a substantial number of studies regarding the development ofmathematical models in recent years, the dynamic behavior of the process is not well comprehendedunder these stressful environments and constantly changing conditions. In this regard, this studyaims to develop a mathematical model for the alcoholic fermentation process in a fed-batchbioreactor under conditions that mimic first-generation (1G) ethanol production in Brazil. Thismodel will consider the thermal effects, energy balances, and substrate concentrations in the kineticparameters of the process. Furthermore, we aim to fulfill the lack of experimental data regarding theheat released during cellular growth and ethanol production, applying a calorimetric analysis of theprocess under specific metabolic stages achieved via chemostat cultivations. For that, we proposethe calorimetric investigation of the widely used industrial S. cerevisiae strain PE-2 using thevalidated setup reported by Schubert et al. (2007) in five distinct metabolic stages that decouplegrowth and ethanol production as far as possible to analyze them separately and determine theirreaction enthalpies experimentally. This project also aims to validate energy and mathematicalmodelling in the industrial 1G ethanol production using previously developed synthetic molasses.Therefore, the proposed model complements the literature by accounting for the impact of essentialprocess variables and the inclusion of energy balances on the traditional mathematical modelparameters.

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