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How diets rich in isoflavone alter the drinking pattern of ethanol

Grant number: 21/09927-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2021
Effective date (End): November 30, 2022
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal researcher:Karina Possa Abrahão
Grantee:Thaynnam Arcebispo Emous
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:19/01686-0 - I cannot stop after the first ‘drink’! Alcohol effects on the inhibitory control brain systems, AP.JP


The abusive use of ethanol is a public health issue and one of the major causes of death around the world. The drinking pattern is an important indicator of the probability of developing addiction and other health issues. Several factors influence ethanol drinking, including different ingredients of diets. A variable component present in commercial rodent chow is the isoflavone. Diets rich with this substance may induce increased ethanol consumption by rodents. This project will study the effect of isoflavones on anxiety-like behavior and how this substance modulates neurogenesis. These approaches will be used to understand how high concentrations of isoflavone may alter drinking patterns in mice. (AU)

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