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Study of cdkn2a gene in patients with thyroid Carcinoma

Grant number: 21/01867-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2021
Effective date (End): November 30, 2022
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Laura Sterian
Grantee:Andressa Teles Pimenta
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Thyroid tumors are the most common malignant neoplasms of the endocrine system and have become increasingly frequent in the population. The p14ARF and p16INK4A proteins, encoded by the CDKN2A gene, play an important role in controlling the cell cycle. Structural and functional alterations of these tumor suppressive proteins are potential risk factors for the development of neoplasias. The present study aims to evaluate the clinical utility of p14ARF and p16INK4A immunohistochemistry protein expression in the detection of CDKN2A polymorphisms in patients with thyroid nodules. We will study 200 patients including 100 differentiated thyroid carcinomas and 200 controls. The polymorphisms will be evaluated using TaqMan SNP Genotyping (7500 Real-Time PCR Systems) and p14ARF and p16INK4A proteins by the immunohistochemistry process. Clinical, laboratory, and imaging data will be obtained from the respective patient records. (AU)

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