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Development and characterization of polymeric films containing curcumin and fluconazole dispersed in nanostructured lipid carriers for the treatment of cutaneous candidiasis

Grant number: 21/11285-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 21, 2022
Effective date (End): December 03, 2022
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Marlus Chorilli
Grantee:Victor Hugo Sousa Araujo
Supervisor abroad: Eliana Maria Barbosa Souto
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Universidade do Minho (UMinho), Portugal  
Associated to the scholarship:19/10261-2 - Evaluation of the potential of nanostructured lipid carriers for co-encapsulation of curcumin and fluconazole dispersed in thermally-responsive hydrogels in the treatment of vulvovaginal candidiasis, BP.DR

Abstract

Cutaneous candidiasis is a cutaneous fungal infection (CFI) commonly diagnosed in dermatological clinics. Currently, the treatment of this pathology involves the oral and cutaneous administration of antimycotic and anti-inflammatory agents. However, oral administration of antifungal drugs is associated with adverse effects and drug interactions, making topical treatment a promising alternative. The increase in clinical isolates with strains resistant to azole agents highlights the need to search for new therapeutic alternatives. In one study, it was shown that the association of curcumin with fluconazole showed synergistic antimycotic potential against strains resistant to azole agents. However, both biomolecules have a lipophilic character, making it necessary to use drug loading systems to better explore their therapeutic potential. Nanostructured lipid carriers (NLC) have been widely used for the delivery of biomolecules for topical application, and due to their high flowability, dispersion in systems that increase their residence time at the site of action is necessary. Polymeric films containing lipids and lipid structures are being studied for cosmetic and therapeutic purposes. However, to date, few studies are found using films for dispersion of NLC, and none use the potential of these systems to treat IFC. Thus, this project seeks to develop and characterize polymeric films containing curcumin and fluconazole dispersed in NLC for the treatment of cutaneous candidiasis.

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