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Can antimicrobial photodynamic therapy and photobiomodulation influence tissue repair on the postoperative of dental surgery in diabetic patients? A blind randomized clinical trial

Grant number: 21/10897-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2021
Effective date (End): November 30, 2022
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Maria Cristina Zindel Deboni
Grantee:Julia Puglia Nunes
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Patients affected by diabetes may present delays in the process of tissue repair. As a systemic condition, diabetes can inhibit several growth factors, decrease local metabolism, and decrease the reparative response due mainly to collagen synthesis. Many adjuvant therapies have been studied to stimulate the repair process in the condition of diabetes. Among the new therapies, Low-Level Laser has stood out due to its modulating effects of wound repair by stimulating cell proliferation and angiogenesis. This study aims to clinically verify the primary outcome of mucosal repair status and as secondary outcomes: bone repair, postoperative pain levels, edema, and oral opening after antimicrobial photodynamic therapy (660nm) (660nm) and low-level laser therapy (808 nm) in diabetic individuals. Twenty diabetic non-insulin-dependent patients in need bilateral exodontic and with glycemia and glycated hemoglobin with maximum values of 110-150mg/dl of blood and up to 7.5%HBa1C, respectively, will be selected. These patients will be allocated in 3 groups, depending on the protocol to be received - aPDT, aPDT+PBM or Sham (simulation of the application of laser irradiation). It will be evaluated: as a primary outcome, mucosal repair by a scale of digital images; as secondary outcomes, bone repair by digital radiographic images that will be compared through a software, pain levels through a visual analog scale, edema by linear measurements and mouth opening through measurements that will be provided with a digital caliper. (AU)

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