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Remineralizing potential of a new toothpaste formulation containing casein phosphopeptide - amorphous calcium phosphate, fluoride and sodium trimetaphosphate: an in situ study

Grant number: 21/10668-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2021
Effective date (End): November 30, 2022
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Marcelle Danelon
Grantee:Julia Paião Quinteiro
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Fluoride and phosphate play an essential role in promoting tooth remineralization. These ions diffuse on the tooth surface, thus promoting an anti-cariogenic effect. The aim of this study was to evaluate in situ, a new toothpaste formulation containing sodium trimetaphosphate (TMP) and amorphous casein-calcium phosphopeptide (CPP-ACP) on the remineralization process of early caries lesions. Blocks (n=192) of bovine teeth will be selected by initial surface hardness (HS), after which they will be subjected to artificial caries lesion induction for 16 hours. The post-demineralization surface hardness (SH1) will be determined. This will be a double-blind, cross-over study, performed in 5 experimental phases lasting 3 days each, and a washout period of 7 days. Volunteers (n=12) will wear palatal devices containing 4 blocks of bovine enamel with artificial caries lesions. The treatment regimens with the experimental toothpaste will be: 1) Placebo (no F-CPP-ACP-TMP), 2) 1100 ppm F (1100F), 3) 1100 ppm F associated with 3% TMP (1100F-TMP), 4) 1100 ppm F associated with 10% CPP-ACP (MI Paste One®) and 5) 1100 ppm F associated with 10% CPP-ACP and 3% TMP (1100F-CPP-ACP-TMP). After the experimental period, the final surface hardness (SH2) and the percentage of surface hardness recovery (%SHR) will be determined. The data will be subjected to normality and homogeneity tests to use the statistical test best suited to the distribution of the data. The statistical software Sigmaplot© for Windows version 12.0 will be used, with significance at the 5% level.(AU)

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