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Determination of fifty-eight aromatic amines in textile products and assessment of pregnant women exposure

Grant number: 21/07994-8
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): September 20, 2021
Effective date (End): September 19, 2022
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Fernando Barbosa Júnior
Grantee:Marília Cristina Oliveira Souza
Supervisor: José Luis Domingo
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Universitat Rovira i Virgili (URV), Spain  
Associated to the scholarship:19/07161-6 - Exposure evaluation to pesticides, polycyclic aromatic hydrocarbons, and toxic elements in Brazilian children: establishment of reference values and possible association with oxidative stress biomarkers., BP.PD

Abstract

The expansion of industrial and agricultural activities has increased human exposure to many toxic substances. After exposure, most of these chemicals can interact with the human organism, leading to a higher predisposition to specific pathologies. Among these chemicals, the aromatic amines (AAs) are a class of emerging pollutants often used as by-products in manufacturing dyes, textiles, plastics, oil refining, leather and rubber manufacturing, and other industrial chemical products. Then, it is essential to conduct studies to determine environmental pollutants concentration in latent sources of exposure as well as in the body fluids of the general population. The results of this approach may assist public health agencies in performing risk assessments and finding populations at risk, mainly more vulnerable, such as children and pregnant women. However, little information is available on the AAs levels in the environment or the level of exposure by the general population. In this sense, the present project aims to determine fifty-eight aromatic amines in textile products commercialized in Spain and Brazil as well as in urine samples from Brazilian pregnant women. The analytes will be determined in 124 textile products and urine samples collected from 300 Brazilian pregnant women (FAPESP Process: 2018/24069-3) by LC-MS/MS. The results of the project will be relevant to support federal agencies of Brazil and Spain in public health policies, establishing baseline values for AAs in textile products, and identifying the general levels of exposure in Brazilian pregnant women. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; ROVIRA, JOAQUIM; HERRERO, MARTA; MARQUES, MONTSE; NADAL, MARTI; BARBOSA JR, FERNANDO; DOMINGO, JOSE LUIS. Assessment of urinary aromatic amines in Brazilian pregnant women and association with DNA damage: Influence of genetic diversity, lifestyle, and environmental and socioeconomic factors. Environmental Pollution, v. 335, p. 8-pg., . (19/07161-6, 21/07994-8, 22/06443-0)
SOUZA, MARILIA CRISTINA OLIVEIRA; CRUZ, JONAS CARNEIRO; CESILA, CIBELE APARECIDA; GONZALEZ, NEUS; ROCHA, BRUNO ALVES; ADEYEMI, JOSEPH A.; NADAL, MARTI; DOMINGO, JOSE L.; BARBOSA, FERNANDO. Recent trends in pesticides in crops: A critical review of the duality of risks-benefits and the Brazilian legislation issue. Environmental Research, v. 228, p. 20-pg., . (19/07161-6, 21/07994-8)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; HERRERO, MARTA; MARQUES, MONTSE; ROVIRA, JOAQUIM; DOMINGO, JOSE L.; BARBOSA JR, FERNANDO; NADAL, MARTI. Non-regulated aromatic amines in clothing purchased in Spain and Brazil: Screening-level exposure and health impact assessment. Journal of Environmental Management, v. 339, p. 8-pg., . (19/07161-6, 21/07994-8, 18/24069-3)
OLIVEIRA SOUZA, MARILIA CRISTINA; DEVOZ, PAULA PICOLI; BIANCHI XIMENEZ, JOAO PAULO; BOCATO, MARIANA ZUCCHERATO; ROCHA, BRUNO ALVES; BARBOSA, FERNANDO. Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 17, p. 11-pg., . (21/07994-8, 18/24069-3, 15/19665-8, 21/03633-0, 19/07161-6)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; HERRERO, MARTA; MARQUES, MONTSE; ROVIRA, JOAQUIM; NADAL, MARTI; BARBOSA, FERNANDO; DOMINGO, JOSE LUIS. Screening of regulated aromatic amines in clothing marketed in Brazil and Spain: Assessment of human health risks. Environmental Research, v. 221, p. 10-pg., . (19/07161-6, 21/07994-8)

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