Advanced search
Start date

Evaluation of the immunomodulatory effect by prednisone drug carried on lipid nanoparticles in a 3D experimental model of Crohn's Disease

Grant number: 21/02207-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2021
Effective date (End): August 31, 2025
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Antonio Claudio Tedesco
Grantee:Nayara Rezende
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


In this proposal, we intend to develop delivery drug systems (DDS) targeted to receptors of IL-12 / IL-23 pro-inflammatory cytokines by specific monoclonal antibodies, seeking to investigate specific uptake and the effect of the drug prednisone in 2D and 3D cellular matrices of the intestinal epithelium of Crohn's disease patients. The DDS aims to improve the therapeutic efficacy of medicines, directly reflecting on the quality of life of the patients and on medical costs in terms of pathology control, a promising approach for the care of various inflammatory diseases. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items