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Miniaturized and/or microfluidic analytical devices for biological applications

Grant number: 21/00205-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2021
Effective date (End): September 30, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Thiago Regis Longo Cesar da Paixão
Grantee:Lauro Antonio Pradela Filho
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications, AP.TEM

Abstract

The development of new devices for fast decision-making is of great interest in the area of analytical chemistry since the analyzes performed in laboratories can take longer for a result when considered the sampling, transport, and analysis of the samples. Thus, the research has been directed to developing new devices that could rapidly and efficiently work at the sampling site, reducing the errors and contamination risks associated with the manual acquisition of samples, storage, and transport. These devices are usually fabricated on microfluidic and/or miniaturized platforms, ensuring better portability to the systems. Also, these devices offer fast analysis and require low sample volumes. As a result, this work consists of developing integrated strategies to monitor species such as cortisol, lactate, nitrite, and glucose in saliva samples since they are important biomarkers for disease diagnoses. Electrochemical and optical detectors will be used to produce portable devices. The devices will be integrated with steps of sample pre-treatment, chemical reactions, separation, and detection. Sensors operating in real conditions for long-term use without loss of response will be desired to determine the species with biological relevance. The objective consists of developing new devices that satisfy the analytical requirements, such as fast response, resistance to the fouling effects, high selectivity, accuracy, and precision. Besides, fabrication methods must meet technological demands, such as large-scale production with low-cost, low energy consumption, and robust electronics. (AU)

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