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Role of endurance training on chronic stress-induced cardiac hypertrophy: involvement of the renin angiotensin system, JNK and p38 MAPK signaling pathways

Grant number: 21/06090-8
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2024
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Dulce Elena Casarini
Grantee:Vinicius Guzzoni
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:17/17027-0 - Hormonal systems in renal and cardiovascular diseases: from cell biology to new physiological paradigms with advances for therapeutics, AP.TEM
Associated scholarship(s):22/15427-9 - Development of a pre-clinical model of adenine diet induced chronic kidney disease in exercise resistant rats, BE.EP.PD


Chronic stress constitutes an alarming public health problem that causes a plenty adverse body effects. It has been observed that the stress-induced harmful effects have been worsened as a result of the coronavirus pandemic. On the other hand, it is well known that stress induces neurohumoral, metabolic and cardiovascular changes, even though those effects are dependent upon the magnitude, type and frequency of the stressor stimulus. In this respect, studies using experimental models are shown to be advantageous once it allows the controlling of variables that affect homeostatic responses to stress. Although some effects of chronic stress are well documented in the current literature, the mechanisms by which stress negatively alters the cardiac morphological and functional adaptations need a better comprehension. It is hypothesized that cardiac maladaptation induced by stress are related to the cardiac Renin-Angiotensin System (RAS) activation accompanied by increasing oxidative stress, although the mechanisms involved in these responses are not yet fully understood. On the other hand, to alleviate the deleterious responses triggered by stress, exercise training has been suggested as a crucial non-pharmacological intervention, whose benefits have been widely reported in the scientific literature. However, whether endurance training modulates both the RAS-related signaling pathways and alter cardiac oxidative stress induced by chronic stress, further studies are necessary. Therefore, the aim of this project is to elucidate the effect of endurance training on the development of pathological cardiac hypertrophy due to chronic stress, using animal model. In this regard, analyzes of cardiac function and structure of heart will be performed, RAS activation, signaling pathways of the protein kinases activated by mitogens (MAPKs), JNK and p38, as well as the role of enzymatic complex NADPH oxidase (Nox). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUZZONI, VINICIUS; SANCHES, ANDREA; COSTA, RAFAELA; DE SOUZA, LIVIA BRUNI; FIROOZMAND, LILIA TADDEO; DE ABREU, ISABEL CRISTINA MALLOSTO EMERICH; GUERRA, JOYCE FERREIRA DA COSTA; PEDROSA, MARIA LUCIA; CASARINI, DULCE ELENA; MARCONDES, FERNANDA KLEIN; et al. Stress-induced cardiometabolic perturbations, increased oxidative stress and ACE/ACE2 imbalance are improved by endurance training in rats. Life Sciences, v. 305, p. 15-pg., . (13/00798-2, 21/06090-8)

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