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Investigation of the biosynthesis of fungal terpenes

Grant number: 20/12564-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2026
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal researcher:Roberto Gomes de Souza Berlinck
Grantee:Kalil Araújo da Silva
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:19/17721-9 - The role of Chemistry in holobiont adaptation, AP.BTA.TEM

Abstract

Phomactins are diterpenes that inhibit the receptor of the platelet aggregating factor. They also reduce the repopulation of tumor cells after radiation therapy. The fungus Biatriospora sp. CBMAI 1333 produces new phomactins. Bioinformatics analysis of the genome of Biatriospora sp. CBMAI 1333 indicated terpenes-cyclase that may be involved in the biosynthesis of phomactins. The present project consists of the complete elucidation of the biosynthesis pathway of phomactins produced by the fungus Biatriospora sp. CBMAI 1333. (AU)

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