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Bacterial identification of the gallbladder and gallstones of patients undergoing cholecystectomy due to complicated and uncomplicated cholelithiasis: changes in the epidemiological scenario

Grant number: 20/15767-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2021
Effective date (End): June 30, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Mauro José Costa Salles
Grantee:Bruno Henrique Nunes Hirata
Host Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil


Cholelithiasis is a disease of the digestive system with high prevalence in the world. In Brazil, it is a routine condition, whose studies suggest a prevalence of around 10% of adults. Bacterial colonization of bile and gallstones can occur in cholelithiasis and occurs when there is cholestasis and bacterial proliferation. This proliferation is facilitated by the ability of some bacteria to adhere (in the form of biofilm). There are also lithogenic processes that involve bacterial participation. Recent studies have shown changes in the gallbladder microbiota of patients undergoing cholecystectomy due to complicated and uncomplicated cholelithiasis, which can impact empirical treatment with antibiotics. Objective: This study intends to characterize the microorganisms collected, their sensitivity profile, clinical manifestations and their influences on the epidemiology of patients undergoing cholecystectomy due to complicated and uncomplicated cholelithiasis. In addition, the study proposes an identification of the bacteria present in bile, which can help in understanding the lithogenic processes and bacterial colonization in the calculations and improve medical care for these patients. Methods: from February 2021 to December 2021, gallstones and bile samples from all patients over 14 years of age with cholelithiasis who undergo cholecystectomy due to uncomplicated cholelithiasis or acute cholecystitis will be analyzed at the Microbiology Department of Santa Casa de São Paulo School of Medical Sciences for microbial culture. Microbial culture, identification and antibiotic resistance testing will be performed according to a standard routine.

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