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Synthesis of an experimental vehicle for the application of nanometric Beta-TCP particles functionalized with fluoride and stannous for the control of dentin surface loss and dentin hypersensitivity

Grant number: 20/07986-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2021
Effective date (End): February 28, 2025
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Taís Scaramucci Forlin
Grantee:Leonardo Custódio de Lima
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):22/00633-2 - New approach to delivery beta: tricalcium phosphate nanoparticles for tooth remineralization, BE.EP.DR


This study aims to: 1. formulation of new materials containing nanometric beta-tricalcium phosphate (Beta-TCP) particles functionalized with fluoride or fluoride plus stannous; 2. to assess the effectiveness of these materials in reducing dental permeability and erosive dentin wear. The study will be divided into two phases. In the first, a gel and a varnish containing the nanoparticles will be formulated and these will be characterized by analyzing the release of calcium, phosphorus and fluoride. For comparison, a commercial fluoride gel and varnish, and placebo gel and varnish will be used. A group without treatments will be also included. In the second phase, the ability of the materials to promote dentin tubule occlusion, reduce its permeability and decrease surface loss will be determined after treatment and after an abrasive/erosive cycle. Human dentin specimens (n = 12), will be immersed for 5min in 17.5% EDTA solution for a simulated hypersensitive dentin, receive the treatments and will be submitted to 5 days of erosion-abrasion cycle (5min in a 0.3 % citric acid solution, followed by 60 min immersion in artificial saliva, 4x/day; 30 min after the first and the fourth erosive challenge, and then toothbrushing with a suspension of a standard toothpaste, 1450 ppm F-, as NaF, will be done for 15s, with 2min of exposure to the suspension). Data will be analyzed statistically, considering ±=0.05. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, LEONARDO CUSTODIO; CARVALHO, ADRIANA OLIVEIRA; BEZERRA, SAVIO JOSE CARDOSO; GARCIA, RAISSA MANOEL; CANEPPELE, TACIANA MARCO FERRAZ; BORGES, ALESSANDRA BUHLER; SCARAMUCCI, TAIS. Tooth color change promoted by different whitening toothpastes under alternate cycles of staining and brushing. Journal of Dentistry, v. 132, p. 10-pg., . (20/07986-2)
LAÍS GATTI DE SOUZA PEREIRA; SÁVIO JOSÉ CARDOSO BEZERRA; ÍTALLO EMÍDIO LIRA VIANA; LEONARDO CUSTÓDIO DE LIMA; ALESSANDRA BÜHLER BORGES; TAÍS SCARAMUCCI. Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion. Brazilian Dental Journal, v. 33, n. 4, p. 54-61, . (20/07986-2)

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