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Potentially inappropriate medications for elderly people in the Sistema Único de Saúde and their therapeutic alternatives

Grant number: 21/01474-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2021
Effective date (End): February 28, 2022
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Eliane Ribeiro
Grantee:Bruno Siraiama
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


In Brazil and around the world, populational aging has become even more meaningful, as well as the diseases related to it. Therewith, there is the increase of medication use, and in this context, potentially inappropriate medications for elderly people - whose risks overcome the benefits - bring about several negative effects to this population. In this scenario, using identification tools, multiple researchers looked for these medications in the standardized lists from the Brazilian public health system "Sistema Único de Saúde", which have an important role related to drug access in the country. However, both lists and tools are updated regularly, and because of it, papers that make use of the newest parameters are relevant, since no recent article was found. In this manner, this study intends to identify and propose substitutes to potentially inappropriate medications for elderly people that are present in the current essential drugs lists from the "Sistema Único de Saúde": the national one (RENAME 2020) and the one from the city of São Paulo (REMUME-SP 2016). To do so, it will be done a descriptive study which will compare these standardized lists to the latest versions of STOPP (2015) e Beers (2019) criteria, plus recognize therapeutic alternatives that are present in the same essential drugs lists and in the UpToDate® and Micromedex® databases. With these results, it plans to exhibit and promote a safer medications list to elderly people by publishing an article, in order to assist in clinical decision making and collaborate to future incorporations to the essential drugs lists of the country. (AU)

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