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Evaluation of torque teno virus in blood and saliva of cirrhotic patients

Grant number: 21/00708-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2021
Effective date (End): December 31, 2021
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Karem López Ortega
Grantee:Ana Clara Falabello de Luca
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


A cirrhotic liver is deficient in several physiological processes in the body, such as the important damage to the immune system, mainly due to the failure of the reticuloendothelial system. The development of immune dysfunction associated with cirrhosis corresponds to a systemic inflammation, which causes an important immunodeficiency state in these patients. Another physiological process affected in cirrhotic patients is excretion, which results in the accumulation of toxic nitrogenous components, which can potentiate systemic inflammation and contribute to viral latency. Thus, it is necessary to investigate the viral load present in these patients, and its relationship with the clinical picture of cirrhosis, in order to understand the relationship between the incidence of viral infection and the state of immunosuppression in these patients. (AU)

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