Role of histone acylations in linking gene expression to cellular metabolism in the gut

Abstract

Protein Posttranslational Modifications (PTMs) link to metabolic states through their dependence on precursor molecules such as ATP or acetyl-CoA. This is also true for PTMs of histones which are an important facet of gene regulation. The newly discovered range of histone acylations, such as crotonylation, adds a new layer of complexity to this molecular process. The nexus between histone modifications and metabolism may be particularly important in the intestinal epithelium. We will employ state-of-the-art approaches, including single cell transcriptome and chromatin analysis, to reveal how alternative histone acylations coordinate gene expression with metabolism in the intestinal epithelium. (AU)