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Functional Characterization of subunit 5 from Anaphase Promoter Complex

Grant number: 21/03212-5
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2021
Effective date (End): March 31, 2023
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Cooperation agreement: Max Planck Society for the Advancement of Science
Principal researcher:Nubia Barbosa Eloy
Grantee:Luís Felipe Correa da Silva
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP


The Anaphase Promoter Complex (APC) is a multiprotein complex - an ubiquitin E3 ubiquitin ligand - involved in ubiquitin-dependent proteolysis of cell cycle regulatory proteins, and in which we include the destruction of mitotic cyclins during the metaphase to anaphase transition. The identification of the complete set of genes encoding the APC subunits in Arabidopsis, suggests that the basic processes controlled by ubiquitin-mediated proteolysis in plants are similar to those of other organisms. However, results from several groups indicate that the APC has other specific functions in the regulation of plant development. In this project, our goal is the functional characterization of subunit 5 of APC from Arabidopsis thaliana, through the production of transgenic plants overexpressing the gene, therefore understand its function for plant development. (AU)

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