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Study of redox reactivity and release of nitric oxide and carbon monoxide in trinuclear ruthenium carboxylates

Grant number: 21/02802-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2021
Effective date (End): May 31, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Sofia Nikolaou
Grantee:Amanda Batista Silva
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


This research project, under Prof .Dr. Sofia Nikolaou supervision, aims to study the redox reactivity of nitrosyl and carboxyl trinuclear ruthenium carboxylates. This initiative is motivated by the physiological and pharmacological functions of carbon monoxide and nitric oxide, as well as by the trinuclear ruthenium carboxylates interesting redox properties and the big number of redox reactions in biological environment. Another interested point of this proposal lies on the fact that this approach is unprecedented, since most of NO release studies in nitrosyls with general formula [Ru3O(CH3COO)6(L)2NO]PF6 (L = N-heterocyclic ligands) has focused on light stimulus. Therefore, the mechanisms and intermediate of its reductive stimulus release are still unknown. In the other hand, the CO release by oxidative chemical stimulus in carboxylates with general formula [Ru3O(CH3COO)6(L)2CO] has not been studied until the present moment. In view of this, the [Ru3O(CH3COO)6(py)2NO]PF6 and [Ru3O(CH3COO)6(py)2CO]0 (where py is the N-heterocyclic ligand pyridine) complexes will be synthesized and characterized and, , as they are complexes already described in the literature, it will allow us a greater focus on the unpublished reactivity studies. Once the complexes are synthesized, the reactivity data will be obtained by ultraviolet and infrared spectrum analyses from the behavior of this complexes in different solvents with and without reducer or oxidizer. Because these compounds are sensible to light, this tests will be done in the dark. Reached the objectives of this project, it is intended to deepen the studies by quantitative data collecting and kinetic modeling of the reactions mechanisms to obtain a wider view of this research theme.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CACITA, NATACHA; SILVA, AMANDA BATISTA; DOS SANTOS, NICOLLE AZEVEDO PORTELA; RAMOS, LOYANNE CARLA BARBOSA; DEL LAMA, MARIA PERPETUA FREIRE DE MORAES; NAAL, ROSE MARY ZUMSTEIN GEORGETTO; NIKOLAOU, SOFIA. Interactions with HSA, anticancer and antiallergic activity of binuclear mu-oxo bridged ruthenium acetate compounds. CHEMISTRYSELECT, v. 8, n. 13, p. 10-pg., . (22/03478-8, 21/02802-3, 18/18060-3, 19/14170-1)
PORTELA DOS SANTOS, NICOLLE AZEVEDO; SILVA, AMANDA BATISTA; NEVES DA SILVA, CAMILA FONTES; PEREIRA ALEXIOU, ANAMARIA DIA; NIKOLAOU, SOFIA. novel triruthenium nitrosyl bearing a quinolinic ligand: a comparison of its spectroscopic behavior with its pyridine analogue. NEW JOURNAL OF CHEMISTRY, v. 46, n. 10, p. 4819-4826, . (21/02802-3, 19/03195-3, 18/18060-3, 19/14170-1)

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