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Expression and activity of ADAM10 and levels of insulinic route proteins in neuroblastoma cells under hyperglycemic and normoglycemic conditions

Grant number: 21/01906-0
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2021
Effective date (End): May 31, 2023
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Márcia Regina Cominetti
Grantee:Marina Mantellatto Grigoli
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by predominant cortical atrophy of the medial temporal lobe and microscopically, by extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. Since the results of the Rotterdam studies in 1992, type 2 Diabetes mellitus (DM2) has been known to increase the risk of dementia. Patients with DM2 show structural brain changes and cognitive impairment with a high risk of developing AD. These results suggest that insulin can play one fundamental role in relation to brain activity and memory formation. From these findings, the AD has been called by some researchers "Diabetes type 3" (DM3) or "brain diabetes". Some search groups show that ADAM10 (ADisintegrin And Metalloprotease), the alfa secretase that inhibits the formation of the senile plaques and therefore, is protective against AD, and is altered in the blood of the elderly with this dementia when compared with cognitive healthy elderly. In this sense, the objective of this study is to check ifa difference at ADAM10 levels and activity exists in neuroblastoma cells (SH-SY5Y) cultivated in normal middle cellular and hyperglycemic, in one condition that simulates the DM2 as well as concurrent alterations of proteins levels involved in the insulin route. The clinical impact of this studyit is related to the best clinical approaches to treating Alzheimer´s disease observing the metabolicstate the patients. (AU)

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