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Identification of the presence of insect specific viruses (ISV) in Aedes aegypti and space-temporal correlation with the distribution of arbovirus infections in São José do Rio Preto

Grant number: 21/01260-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2021
Effective date (End): December 31, 2021
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Caio Patuto Pereira
Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil


Since the first cases of arboviruses were reported in Brazil, the country has constantly suffered from epidemics of mosquito-borne diseases. The vector with the greatest importance for Brazilian public health is the mosquito of the Culicidae family, Aedes aegypti. This vector is responsible for the transmission of endemic arboviruses throughout the national territory, with emphasis on dengue, Zika, chikungunya and yellow fever. Although most cases do not progress to more severe conditions, there is great potential for chronic evolution, the occurrence of severe sequelae and, in more extreme cases, death. One of the ways to better understand arboviruses is to study the relationship of insect specific viruses (ISVs) and their interference relationship with pathogenic arboviruses. It is believed that the Phasi Charoen-Like virus (PCLV) and the Humaita-tubiacanga virus (HTV), both ISVs, may have an interference relationship with arboviruses transmitted by Aedes aegypti mosquitoes, and this interference would be positive for humans. , where ISVs would interfere, through a relationship of viral competition, in the multiplication and transmission of viruses that cause arboviruses. This study aims to identify ISVs in an endemic region for arboviruses and to spatially and temporally correlate their presence with dengue, Zika and chikungunya epidemics.

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