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Radiogenomics: magnetic resonance and different subtypes of breast carcinomas

Grant number: 20/10448-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2021
Effective date (End): February 28, 2022
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:EDUARDO CARVALHO PESSOA
Grantee:Júlia Araújo de Oliveira
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Breast cancer is a complex and heterogeneous disease, with specific subtypes of tumors associated with different prognosis. Currently, the genomic classification of the different molecular types of breast tumors is a key point in the clinical management of patients, allowing thepersonalization of treatment and avoiding unnecessary actions and side effects efeitos. However, genomic analysis has limited usefulness due to thecomplexity and high cost², making their integration an obstacle in the reality of SUS health services and most health plans. The attempt to correlate the biological behavior of tumors with the image patterns gave rise to radiogenomics, which represents the evolution from the radiology-pathology correlation at the anatomical-histological level to the phenotypic correlation with the molecular and gene profile. That said,our study has as its primary objective to evaluate the predictors of breast resonance pre-established by BI-RADS, linking them to the different subtypes of cancer classified by immunohistochemistry, and then seek to find predictors that may signal more or less aggression tumor biological.

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