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Relationship between inflammation and primary metabolism in the postprandial period

Grant number: 20/16542-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): March 01, 2021
Effective date (End): February 29, 2024
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Bernadette Dora Gombossy de Melo Franco
Grantee:Carlos Mario Donado Pestana
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07914-8 - FoRC - Food Research Center, AP.CEPID


The postprandial period comprises the first hours after the intake of a meal, when nutrients are being absorbed in the small intestine. In this timeframe, plasma levels of dietary compounds, intermediates of primary metabolism and signalling molecules undergo rapid changes, in contrast to their values in the post-absorptive (basal) state. These changes trigger an acute inflammatory response, measurable as changes in pro-inflammatory cytokines, oxylipins and other humoral mediators of inflammation, but also in terms of changes in the number of circulating immune cells and their gene expression pattern. Despite being scarcely understood, postprandial inflammation has been an active topic of research in the last decade, leading to the understanding that meal composition plays a role in this phenomenon which is thought to be proportional to the fat content of the ingested food. It is also important to note that although postprandial inflammation happens under normal physiological circumstances, it can be associated to chronic diseases such as insulin resistance and Obesity. The naturally large interindividual variability in postprandial metabolic and inflammatory changes poses an obstacle to their understanding. Changes in metabolite concentrations and inflammatory markers are prone to a high degree of variability amongst individuals, which is the result of numerous variables involved in the digestion, absorption and metabolism of dietary compounds. Understanding the relationship between plasma metabolite changes in the hours following the intake of a meal and the development of postprandial inflammation, as well as mapping the natural interindividual variability is key to understand how these changes are linked to health and disease and how to intervene in this phenomenon. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOURA, MARCIO H. C.; DONADO-PESTANA, CARLOS M.; RODRIGUES, LARISSA; PESSOA, ERIKA V. M.; ROSSI E SILVA, RAFAELA; FESTUCCIA, WILLIAN T.; GENOVESE, MARIA INES. Long-term supplementation with phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) reduces adiposophaty and improves glucose, lipid, and energy metabolism. Food Research International, v. 143, . (18/24477-4, 20/16542-0)
DOS SANTOS-DONADO, PRISCILA R.; DONADO-PESTANA, CARLOS M.; TANAKA, FRANCISCO A. OSSAMU; VENTURINI, ANNA C.; DELGADO, EDUARDO FRANCISQUINE; CONTRERAS-CASTILLO, CARMEN J.. Effects of high-oxygen, carbon monoxide modified atmospheres and vacuum packaging on quality of Longissimus thoracis et lumborum steaks from Nellore cows during ageing. Food Research International, v. 143, . (10/08182-2, 20/16542-0, 09/13559-0, 17/26667-2, 19/18346-7)

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