Inhibition of chaperones with violacein in Saccharomyces cerevisiae

Grant number:	20/15068-3
Support Opportunities:	Scholarships in Brazil - Scientific Initiation
Effective date (Start):	March 01, 2021
Effective date (End):	February 28, 2022
Field of knowledge:	Biological Sciences - Parasitology

Principal Investigator:	Elizabeth Bilsland
Grantee:	Lucas Jung Eberhardt

Host Institution:	Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract Violacein is a natural compound with antibacterial, antiparasitic and antitumor activity. Several published studies have shown that violacein induces apoptosis, but the mechanism for this has remained unclear. Using a genomic chemical profile in yeasts, we have identified direct targets of violacein: chaperones Hsp70. The present work aims to elucidate the cellular effects of the inhibition of Hsp70 chaperones in yeast cells.

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