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Characterization of the sweat test in Brazil: an epidemiological study

Grant number: 20/03342-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2021
Effective date (End): December 31, 2021
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Fernando Augusto de Lima Marson
Grantee:Luan Victor Frota de Azevedo
Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil


The sweat test is the gold standard for the diagnosis of cystic fibrosis (CF). However, the test has high variability and it is associated with several markers such as the residual expression of the CFTR protein, environmental factors and characteristics of the individual (for example, sex, age, body mass index and genetic variability). Aims: Associate the sweat test data in CF patients in Brazil, according to demographic, clinical and laboratory characteristics. Methods: The Brazilian Cystic Fibrosis Study Group will be contact to provide the data regarding the sweat test ([Cl-], [Na+] and sweat weight) and the CFTR genotype of CF patients nationwide. These data will be associated with the demographic, clinical and laboratory characteristics from patients with CF. Expected results: To describe the results of the sweat test in CF patients in Brazil, according to the demographic characteristics of the different federative units. The results of the sweat test will be described in the study [mainly the value of Cl- (mEq/L), and, if available, the value of Na+ (mEq/L)]; as well as its association with epidemiological data, which includes sex (male or female), age (in months, at the time of the sweat test), genotype of the CFTR gene, clinical condition of the patient (digestive, pulmonary or both), weight (kg) and height (or length, in cm, at the time of the sweat test), and immunoreactive trypsinogen value (in ng/mL, if performed). The prevalence of sweat tests with normal or boderlines values in patients with the presence of two variants known to be pathogenic in the CFTR gene will also be tabulated.

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