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Respiratory changes elicit by neurokinin receptors at the level of the retrotrapezoid nucleus

Grant number: 19/20504-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2021
Effective date (End): August 31, 2023
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Thiago dos Santos Moreira
Grantee:Octávio Augusto de Carvalho Maia
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/23376-1 - Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity, AP.TEM


Ventilation is a physiological process that depends on the integration of neural networks, which is essential for maintaining the internal physiological balance. All this mechanism has the main objective to maintain adequate levels of O2 and CO2 in the blood and tissues. It is well established that central and peripheral chemoreceptors detect changes in arterial blood gas concentrations and transmit this information to respiratory centers in order to regulate respiratory activity. There are many important regions in chemoreception, including the Retrotrapezoid Nucleus (RTN). In the RTN, the central chemoreception mechanism involves activation of chemosensitive neurons, which detect changes in CO2/pH, possibly being modulated by neurokinin signaling. Thus, the main objective of this project will be to investigate the participation of neurokinin receptors, located in the region of the RTN, in the central and/or peripheral chemoreceptors stimulation and a possible integration with serotonergic signaling. The experiments developed in this project will use genetically modified mice, as well as the injection of viral vectors and techniques for recording respiratory activity through whole body plethysmography. (AU)

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