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The role of bioactive, resinous and fluoridated agents in the treatment of dentin hypersensitivity and their interaction with sound and eroded dentin: in vitro and clinical studies

Grant number: 19/21128-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2021
Effective date (End): June 30, 2024
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Linda Wang
Grantee:Victor Mosquim
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated scholarship(s):21/07513-0 - Dentinal tubules occlusion after application of experimental toothpastes containing bioactive glasses: a magical angle spinning-nuclear magnetic resonance (MAS-NMR) analysis, BE.EP.DR


Dealing with dentin hypersensitivity treatment faces the challenge to reach a long-term relief effect. Searching for innovation implies in feasible strategies, which require the analyses of their mechanism (physical-chemical) and translation to clinical scenario. The objective of this work will be to evaluate, under different aspects, the action of a glutaraldehyde-based desensitizer (Gluma® Desensitizer Power Gel) and a vehicle containing the S-PRG Giomer technology (S- PRG Barrier Coat®) compared to essentially chemical technologies: a 5% fluoro-calcium phosphosilicate-based toothpaste (BioMin F®), an amine fluoride, tin chloride and chitosan-containing toothpaste (Elmex Erosion Protection®), a fluoride varnish with 5% NaF (2,26% of F, Duraphat®) and a fluoride varnish containing TiF4 at 4% (2,45% of F). In vitro physicochemical properties and clinical performance will be evaluated to verify their mechanisms of action and interaction with dentin. Initially, the materials will be chemically characterized by X-ray spectroscopy (EDX) and a 3¼L aliquot will be analyzed by Fourier Transform Infrared Spectroscopy (FTIR) for analysis of the interaction of these materials with sound and artificially eroded human dentin. The Degree of Conversion (DC) analysis of the SPRG Barrier Coat® will also be analyzed. Then 1±0.2 mm-thick dentin discs will be analyzed before and after application of these materials to evaluate the reduction of dentin hydraulic conductivity (Lp) in the Flodec device. Finally, BioMin F® and Elmex Erosion Protection® toothpastes will be applied in a randomized controlled clinical trial in DH patients for three weeks and compared to a 5% NaF (Duraphat®) varnish, to a 4% TiF4 varnish and to each other for 1 and 3 months. Data will be analyzed for normality and homogeneity (Kolmogorov and Smirnov test and Bartlett test, respectively) and, if approved, will be subjected to appropriate parametric tests. Otherwise, they will be analyzed using nonparametric tests, followed by appropriate post-hoc tests. In all cases, the significance level will be set at 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICTOR MOSQUIM; GIOVANNA SPERANZA ZABEU; GERSON APARECIDO FORATORI-JUNIOR; ALESSANDRA BUHLER BORGES; DANIELA RIOS; ANA CAROLINA MAGALHÃES; LINDA WANG. S-PRG-based toothpastes compared to NaF toothpaste and NaF varnish on dentin permeability in vitro. Journal of Applied Oral Science, v. 30, . (19/20970-0, 19/21128-1)
MOSQUIM, VICTOR; CARACHO, RAFAELA APARECIDA; ZABEU, GIOVANNA SPERANZA; CONDI, LUIZA DA SILVEIRA; FORATORI-JUNIOR, GERSON APARECIDO; BORGES, ANA FLAVIA SANCHES; WANG, LINDA. Resin-based materials to control human dentin permeability under erosive conditions in vitro: A hydraulic conductance, confocal microscopy and FTIR study. Dental Materials, v. 38, n. 10, p. 10-pg., . (19/21128-1, 19/20970-0)
FRANCISCONI-DOS-RIOS, LUCIANA FAVARO; DANTAS, LUCIANA MASCARENHAS; CALABRIA, MARCELA PAGANI; PEREIRA, JOSE CARLOS; MOSQUIM, VICTOR; WANG, LINDA. Obliterating potential of active products for dentin hypersensitivity treatment under an erosive challenge. Journal of Dentistry, v. 112, . (19/21128-1)

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